Physical map location of the Escherichia coli gene encoding the bifunctional enzyme 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methenyl-tetrahydrofolate cyclohydrolase
نویسندگان
چکیده
منابع مشابه
The crystal structure of a bacterial, bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase.
The structure of a bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/cyclohydrolase from Escherichia coli has been determined at 2.5 A resolution in the absence of bound substrates and compared to the NADP-bound structure of the homologous enzyme domains from a trifunctional human synthetase enzyme. Superposition of these structures allows the identification of a highly conserved clust...
متن کامل[Mutations in the methylene-tetrahydrofolate reductase gene and Down syndrome].
Down syndrome (DS) is a complex genetic and metabolic disorder attributed to the presence of three copies of chromosome 21. The extra chromosome derives from the mother in 93% of cases and is due to abnormal chromosome segregation during meiosis (nondisjunction). Except for advanced age at conception, maternal risk factors for meiotic nondisjunction are not well established. A recent preliminar...
متن کاملMethylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major.
10-Formyl tetrahydrofolate (10-CHO-THF) is a key metabolite in C1 carbon metabolism, arising through the action of formate-tetrahydrofolate ligase (FTL) and/or 5,10-methenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase (DHCH). Leishmania major possesses single DHCH1 and FTL genes encoding exclusively cytosolic proteins, unlike other organisms where isoforms occur...
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E. coli contains a single acyl-CoA synthetase, which has been purified to homogeneity (3, 4). In the process of long-chain fatty acid transport, this enzyme plays a pivotal role by catalyzing the thioesterification of exogenous fatty acids into metabolically active CoA thioesters prior to 3-oxidation concomitant with transport. This enzyme has broad chain-length specificity, giving Vm. values r...
متن کاملPhysical map location of the Escherichia coli gene encoding phosphoglycerol transferase I.
Membrane-derived oligosaccharides (MDO) are found as soluble components of the periplasmic compartment of Escherichia coli (15). They are a family of closely related oligosaccharides containing 6 to 10 glucose units joined by 3-1,2 and 3-1,6 linkages and are variously substituted with succinic acid 0 ester, phosphoethanolamine, and sn-1-phosphoglycerol (7, 14). The mdoB locus (4, 5) encodes pho...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1991
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.173.17.5251.1991